ENTRY       EC 3.1.21.4
NAME        Type II site-specific deoxyribonuclease
            Type II restriction enzyme
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of DNA to give specific double-stranded
            fragments with terminal 5'-phosphates
SUBSTRATE   DNA
            H2O
PRODUCT     DNA 5'-phosphate
COFACTOR    Magnesium
COMMENT     This is a large group of enzymes which, together with those now
            listed as EC 3.1.21.3 and 3.1.21.5, were previously listed
            separately in sub-subclasses 3.1.23 and 3.1.24. They require only
            Mg2+. They recognize specific short DNA sequences and cleave
            either within, or at a short specific distance from, the
            recognition site. A complete listing of all these enzymes has been
            produced by R.J.Roberts; this list is updated annually.
            Roberts,R.J.(1983) Nucleic Acids Res., 11, r135.
MOTIF       PS: PS00092  [LIVAC]-[LIVFYWA]-x-[DN]-P-P-[FYW]
GENES       MJA: MJ0600 MJ0984
            ECO: b4345(mcrC)
            HIN: HI0512(hinDIIR) HI1040 HI1393(hindIIIR)
            SYN: mcrA) sll1193(ECOLI_1121 slr0061 slr1302
STRUCTURES  PDB: 1ERI  1RVE  1RVC  1RVB  1RVA  1PVU  1BHM  1CFR  1BAM  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.21.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.4
            SCOP (Structural Classificaion of Proteins): 3.1.21.4
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