ENTRY       EC 3.1.21.1
NAME        Deoxyribonuclease I
            Pancreatic DNase
            DNase
            Thymonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphodinucleotide and
            5'-phosphooligonucleotide end-products
SUBSTRATE   DNA
            H2O
            Double-stranded DNA
PRODUCT     5'-Phosphodinucleotide
            5'-Phosphooligonucleotide
COMMENT     Preference for double-stranded DNA. Similar enzymes: Streptococcal
            DNase (Streptodornase); T4 endonuclease II; T7 endonuclease II; E.
            coli endonuclease I; "Nicking" enzyme of calf thymus; Colicin E2
            and E3. Formerly EC 3.1.4.5.
DISEASE     MIM: 125505  Deoxyribonuclease I
MOTIF       PS: PS00918  Y-D-D-G-C-E-x-C-G-N-D
            PS: PS00919  [KR]-x-F-A-I-V-[AP]-L-H-[SA](2)-P
GENES       ECO: b2945(endA)
            HSA: DNASE1(DNL1)
STRUCTURES  PDB: 1DNK  2DNJ  3DNI  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.21.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.1
            SCOP (Structural Classificaion of Proteins): 3.1.21.1
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