ENTRY       EC 3.1.2.6
NAME        Hydroxyacylglutathione hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     S-(2-Hydroxyacyl)glutathione hydrolase
REACTION    S-(2-Hydroxyacyl)glutathione + H2O = Glutathione +
            a 2-Hydroxycarboxylate
SUBSTRATE   S-(2-Hydroxyacyl)glutathione
            H2O
PRODUCT     Glutathione
            2-Hydroxycarboxylate
COMMENT     Also hydrolyses S-acetoacetylglutathione, more slowly.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DISEASE     MIM: 138760  Hydroxyacyl glutathione hydrolase; glyoxalase II;
                         [Glyoxalase II deficiency] (1)
GENES       ECO: b0212(gloB)
            SYN: sll1019
            HSA: HAGH
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.2.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.6
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