ENTRY       EC 3.1.2.15
NAME        Ubiquitin thiolesterase
            Ubiquitin carboxy-terminal esterase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Ubiquitin-C-terminal-thiolester hydrolase
REACTION    Ubiquitin C-terminal thiolester + H2O = Ubiquitin + a Thiol
SUBSTRATE   Ubiquitin C-terminal thiolester
            H2O
            Dithiothreitol
            Glutathione
            C-terminal glycine residue of the polypeptide ubiquitin
            AMP-ubiquitin
PRODUCT     Ubiquitin
            Thiol
COMMENT     Acts on esters formed between thiols such as dithiothreitol or
            glutathione and the C-terminal glycine residue of the polypeptide
            ubiquitin.  Also acts on AMP-ubiquitin.
DISEASE     MIM: 191342  Ubiquitin C-terminal esterase L1
            MIM: 300050  Ubiquitin carboxyl-terminal hydrolase, X-linked
            MIM: 300072  Drosophila fat facets related, X-linked
            MIM: 400005  Drosophila fat facets related, Y-linked
            MIM: 601447  Ubiquitin isopeptidase T
MOTIF       PS: PS00140  N-x-C-G-x(3)-[LIVM](2)-H
            PS: PS00972  G-[LIVMFY]-x(1,3)-[AGC]-[NA]-x-C-[FY]-[LIVMC]-[NS]-
                         [SACV]-x-[LIVM]-Q
            PS: PS00973  Y-x-L-x-[SAG]-[LIVMFT]-x(2)-H-x-G-x(4,5)-G-H-Y
GENES       SCE: YBL067C(UBP13) YBR058C(UBP14) YDL122W(UBP1) YDR069C(UBP4)
                 YER098W(UBP9) YER144C(UBP5) YER151C(UBP3) YFR010W
                 YIL156W(UBP7) YJL197W(UBP12) YJR099W(YUH1) YKR098C(UBP11)
                 YMR223W(YM9959.05) YMR304W(YM9952.06) YNL186W(N1619)
                 YOR124C(UBP2)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.2.15
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.15
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