ENTRY       EC 3.1.15.1
NAME        Venom exonuclease
            Venom phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Exonucleases active with either ribo- or deoxyribonucleic acids
            and producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 3'- to 5'-direction to yield
            5'-phosphomononucleotides.
SUBSTRATE   Nucleotide
            H2O
            Single-stranded nucleotide
PRODUCT     5'-Phosphomononucleotide
COMMENT     Preference for single-stranded substrate. Similar enzymes: Hog
            kidney phosphodiesterase; Lactobacillus exonuclease.
            This enzyme has a 500-1,700-fold greater activity on R(p) isomers
            of RNA containing phosphorothioate such as U-P(S)-A and A-P(S)-A
            than S(p) isomers.  Review: 'Stereochemistry of enzymatic reaction
            of phosphates', P.A.Frey, Tetrahedron 38, 1541 (1982).
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.15.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.15.1
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