ENTRY       EC 3.1.11.2
NAME        Exodeoxyribonuclease III
            E.coli exonuclease III
CLASS       Hydrolases
            Acting on ester bonds
            Exodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 3'- to 5'-direction to yield
            5'-phosphomononucleotides
SUBSTRATE   Deoxyribonucleotide
            Double-stranded DNA
            H2O
PRODUCT     5'-Phosphomononucleotide
COMMENT     Preference for double-stranded DNA. Has endonucleolytic activity
            near apurinic sites on DNA. Similar enzyme: Haemophilus influenzae
            exonuclease. Formerly EC 3.1.4.27.
MOTIF       PS: PS00726  [APF]-D-[LIVMF](2)-x-[LIVM]-Q-E-x-K
            PS: PS00727  D-[ST]-F-R-[KH]-x(7,8)-[FYW]-[ST]-[FYW](2)
            PS: PS00728  N-x-G-x-R-[LIVM]-D-[LIVMFYH]-x-[LV]-x-S
GENES       MTH: MTH212
            ECO: b1749(xthA)
            HIN: HI0041(xthA)
            HPY: HP1526(lexA)
            BSU: exoA
            SYN: sll1854(xthA)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.11.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.11.2
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