ENTRY       EC 3.1.1.7
NAME        Acetylcholinesterase
            True cholinesterase
            Choline esterase I
            Cholinesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Acetylcholine aectylhydrolase
REACTION    Acetylcholine + H2O = Choline + Acetate
SUBSTRATE   Acetylcholine
            Acetic ester
            H2O
PRODUCT     Choline
            Acetate
INHIBITOR   Tacrine
COMMENT     Acts on a variety of acetic esters; also catalyses
            transacetylations
            Inhibited by tacrine (Proc.Natl.Acad.Sci.USA 90,9031-9035 (1993)).
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DISEASE     MIM: 100740  Acetylcholinesterase (YT blood group)
MOTIF       PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
GENES       HSA: ACHE
STRUCTURES  PDB: 2ACE  1ACJ  1ACK  1ACL  1AMN  1FSS  1MAH  1VOT  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.1.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.7
            SCOP (Structural Classificaion of Proteins): 3.1.1.7
///