ENTRY       EC 3.1.1.51
NAME        Phorbol-diester hydrolase
            Diacylphorbate 12-hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     12,13-Diacylphorbate 12-acylhydrolase
REACTION    Phorbol 12,13-dibutanoate + H2O = Phorbol 13-butanoate + Butanoate
SUBSTRATE   Phorbol 12,13-dibutanoate
            H2O
PRODUCT     Phorbol 13-butanoate
            Butanoate
COMMENT     Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols
            (phorbol is a detetpenoid) this reaction inactivates tumour
            promoter 12-O-tetradecanoylphorbol-13-acetate from croton oil.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.1.51
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.51
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