ENTRY       EC 3.1.1.4
NAME        Prophospholipase A2
            Lecithinase A
            Phosphatidase
            Phosphatidolipase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Phosphatidylcholine 2-acylhydrolase
REACTION    Phosphatidylcholine + H2O = 1-Acylglycerophosphocholine +
            a Carboxylate
SUBSTRATE   Phosphatidylcholine
            Phosphatidylethanolamine
            Choline plasmalogen
            Choline phosphatide
            H2O
PRODUCT     1-Acylglycerophosphocholine
            Carboxylate
INHIBITOR   1-Hexadecylthio-2-hexadecanoylamino-1,2-dideoxy-sn-glycero-3-
            $phosphocholine
            1-Hexadecylthio-1-deoxy-2-hexadecylphosphono-sn-glycero-3-
            $phosphocholine
            AACOCF3
COFACTOR    Calcium
COMMENT     Also acts on phosphatidylethanolamine, choline plasmalogen and
            phosphatides, removing the fatty acid attached to the 2-position.
            Requires Ca2+.
            Inhibited by AACOCF3 (trifluoromethyl ketone analogue of
            arachidonic acid (Biochemistry 32, 5935-5940, (1993)).
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
            PATH: MAP00590  Prostaglandin and leukotriene metabolism
DISEASE     MIM: 172410  Phospholipase A2, group IB (pancreas)
            MIM: 172411  Phospholipase A2, group IIA (platelets, synovial
                         fluid); {?Colorectal cancer, resistance to} (1)
MOTIF       PS: PS00118  C-C-x(2)-H-x(2)-C
            PS: PS00119  [LIVMA]-C-{LIVMFYWPCST}-C-D-x(5)-C
GENES       HSA: PLA2G1B(PLA2)
STRUCTURES  PDB: 1AE7  1AYP  1BBC  1BP2  1BPQ  1BUN  1CEH  1CLP  1KVO  1P2P  
                 1PIR  1PIS  1POA  1POB  1POC  1POD  1POE  1PP2  1PPA  1PSH  
                 1PSJ  1SFV  1SFW  1VAP  1VIP  2BPP  2NOT  2PHI  3BP2  3P2P  
                 4BP2  4P2P  5P2P  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.4
            SCOP (Structural Classificaion of Proteins): 3.1.1.4
///