ENTRY       EC 3.1.1.34
NAME        Lipoprotein lipase
            Clearing factor lipase
            Diglyceride lipase
            Diacylglycerol lipase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Triglycero-protein acylhydrolase
REACTION    Triacylglycerol + H2O = Diacylglycerol + a Carboxylate
SUBSTRATE   Triacylglycerol
            H2O
PRODUCT     Diacylglycerol
            Carboxylate
COMMENT     Hydrolyses triacylglycerols in chylomicrons and low-density
            lipoproteins. Also hydrolyses diacylglycerol.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DISEASE     MIM: 238600  Lipoprotein lipase; Hyperlipoproteinemia I (1);
                         Lipoprotein lipase deficiency (3); Chylomicronemia
                         syndrome, familial (3); Combined hyperlipemia, familial
                         (3)
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVST]-G-[HYWV]-S-x-G-[GSTAC]
GENES       HSA: LPL(LIPD)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.1.34
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.34
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