ENTRY       EC 3.1.1.3
NAME        Triacylglycerol lipase
            Lipase
            Triglyceride lipase
            Tributyrase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Triacylglycerol acylhydrolase
REACTION    Triacylglycerol + H2O = Diacylglycerol + a Carboxylate
SUBSTRATE   Triacylglycerol
            H2O
PRODUCT     Diacylglycerol
            Carboxylate
COMMENT     The pancreatic enzyme acts only on an ester-water interface;
            the outer ester links are preferentially hydrolyzed.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DISEASE     MIM: 114840  Carboxyl-ester lipase (bile-salt stimulated lipase)
            MIM: 151670  Lipase, hepatic; Hepatic lipase deficiency (3)
            MIM: 246600  Pancreatic lipase; Pancreatic lipase deficiency (1)
            MIM: 278000  Lipase A, lysosomal acid, cholesterol esterase; Wolman
                         disease (3); Cholesteryl ester storage disease (3)
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVST]-G-[HYWV]-S-x-G-[GSTAC]
            PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00330  D-x-[LI]-x(4)-G-x-D-x-[LI]-x-G-G-x(3)-D
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
            PS: PS01098  [LIVMFYAG](4)-G-D-S-[LIVM]-x(1,2)-[TAG]-G
GENES       BSU: lipA(lip) lipB(yfiP)
            MGE: MG344(lip1)
            MPN: G12_orf272V(lip3) H08_orf289(lip3)
            SYN: sll1969
            SCE: YDR058C(TGL2)
            HSA: CEL(BSSL) LIPB LIPC(Hs.9994) PNLIP(Hs.99950)
STRUCTURES  PDB: 1CRL  1CUA  1CUB  1CUC  1CUD  1CUE  1CUF  1CUG  1CUH  1CUI  
                 1CUJ  1CUU  1CUV  1CUW  1CUX  1CUY  1CUZ  1CVL  1ETH  1FFA  
                 1FFB  1FFC  1FFD  1FFE  1GPL  1HPL  1LBS  1LBT  1LGY  1LPA  
                 1LPB  1LPM  1LPN  1LPO  1LPP  1LPS  1OIL  1TAH  1TCA  1TCB  
                 1TCC  1TGL  1THG  1TIA  1TIB  1TIC  1TRH  2LIP  3LIP  3TGL  
                 4TGL  5TGL  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.3
            SCOP (Structural Classificaion of Proteins): 3.1.1.3
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