ENTRY       EC 3.1.1.25
NAME        1,4-Lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     1,4-Lactone hydroxyacylhydrolase
REACTION    a 1,4-Lactone + H2O = a 4-Hydroxyacid
SUBSTRATE   1,4-Lactone
            H2O
PRODUCT     4-Hydroxyacid
COFACTOR    Calcium
COMMENT     The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It
            does not hydrolyse simple aliphatic esters, acetylcholine, sugar
            lactones or substituted aliphatic lactones, e.g. 3-hydroxy-
            -4-butyrolactone; requires Ca2+.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.1.25
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.25
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