ENTRY       EC 2.7.7.49
NAME        RNA-directed DNA polymerase
            DNA nucleotidyltransferase (RNA-directed)
            Reverse transcriptase
            Revertase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase
            (RNA-directed)
REACTION    Deoxynucleoside triphosphate + DNA(n) = Pyrophosphate + DNA(n+1)
SUBSTRATE   Deoxynucleoside triphosphate
            DNA(n)
PRODUCT     Pyrophosphate
            DNA(n+1)
COMMENT     Catalyses RNA-template-directed extension of the 3'- end of a DNA
            strand by one deoxynucleotide at a time. Cannot initiate a chain
            de novo. Requires an RNA or DNA primer. DNA can also serve as
            template.
            See also EC 2.7.7.7 (EC 2.7.7.7 DNA-directed DNA polymerase)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1UWB  1TVR  1RVR  1RVQ  1RVP  1RVO  1RVM  1RVL  1RTJ  1RTI  
                 1RTH  1VRT  1VRU  1REV  1RDH  1HNV  1HNI  1HMV  1HMI  1HAR  
                 1GNO  1GNN  1GNM  1DLO  1RT2  1RT1  3HVT  1RVN  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.7.49
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.49
            SCOP (Structural Classificaion of Proteins): 2.7.7.49
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