ENTRY EC 2.7.7.46
NAME Gentamicin 2''-nucleotidyltransferase
CLASS Transferases
Transferring phosphorus-containing groups
Nucleotidyltransferases
SYSNAME NTP:gentamicin 2''-nucleotidyltransferase
REACTION Nucleoside triphosphate + Gentamicin = Pyrophosphate +
2''-Nucleotidylgentamicin
SUBSTRATE Nucleoside triphosphate
Gentamicin
ATP
dATP
CTP
ITP
GTP
Kanamycin
Tobramycin
Sisomicin
PRODUCT Pyrophosphate
2''-Nucleotidylgentamicin
2''-Nucleotidylkanamycin
2''-Nucleotidyltobramycin
2''-Nucleotidylsisomicin
COMMENT ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin,
tobramycin and sisomicin can also act as acceptors. The
nucleotidyl residue is transferred to the 2-hydroxyl of
the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
DBLINKS University of Geneva ENZYME DATA BANK: 2.7.7.46
WIT (What Is There) Metabolic Reconstruction: 2.7.7.46
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