ENTRY       EC 2.7.7.31
NAME        DNA nucleotidylexotransferase
            Terminal deoxyribonucleotidyltransferase
            Terminal addition enzyme
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Nucleoside-triphosphate:DNA deoxynucleotidylexotransferase
REACTION    Deoxynucleoside triphosphate + DNA(n) =
            Pyrophosphate + DNA(n+1)
SUBSTRATE   Deoxynucleoside triphosphate
            DNA(n)
PRODUCT     Pyrophosphate
            DNA(n+1)
COMMENT     Catalyses template-independent extension of the 3'- end of a DNA
            strand by one nucleotide at a time. Cannot initiate a chain de
            novo. Nucleoside may be ribo- or deoxyribo-.
            3 and a 3'-OH is required.
DISEASE     MIM: 187410  Terminal deoxynucleotidyltransferase
MOTIF       PS: PS00522  G-[SG]-[LFY]-x-R-[GE]-x(3)-[SGCl]-x-D-[LIVM]-D-
                         [LIVMFY](3)-x(2)-[SAP]
GENES       HSA: DNTT(TDT)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.7.31
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.31
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