ENTRY       EC 2.7.6.1
NAME        Ribose-phosphate pyrophosphokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Diphosphotransferases
SYSNAME     ATP:D-ribose-5-phosphate pyrophosphotransferase
REACTION    ATP + D-Ribose 5-phosphate = AMP +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   ATP
            dATP
            D-Ribose 5-phosphate
PRODUCT     AMP
            dAMP
            5-Phospho-alpha-D-ribose 1-diphosphate
COMMENT     dATP can also act as donor
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00230  Purine metabolism
DISEASE     MIM: 311850  Phosphoribosyl pyrophosphate synthetase-1;
                         Phosphoribosyl pyrophosphate synthetase-related gout
                         (3)
            MIM: 311860  Phosphoribosyl pyrophosphate synthetase 2
MOTIF       PS: PS00114  D-L-H-A-x-Q-[IM]-Q-G-F-F-x(2)-P-[LIVM]-D
GENES       MJA: MJ1366
            MTH: MTH784
            ECO: b1207(prsA)
            HIN: HI1609(prsA)
            HPY: HP0742(prsA)
            BSU: prs
            MGE: MG058(prsA)
            MPN: D09_orf388(prsA)
            SYN: sll0469(prsA)
            SCE: YBL068W(PRPS4) YER099C(PRPS2) YHL011C(PRPS3) YKL181W(PRPS1)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.6.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.6.1
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