ENTRY       EC 2.7.4.3
NAME        Adenylate kinase
            Myokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:AMP phosphotransferase
REACTION    ATP + AMP = ADP + ADP
SUBSTRATE   ATP
            Inorganic triphosphate
            AMP
PRODUCT     ADP
            Pyrophosphate
COMMENT     Inorganic triphosphate can also act as donor.
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 103000  Adenylate kinase-1; Hemolytic anemia due to adenylate
                         kinase deficiency (3)
            MIM: 103020  Adenylate kinase-2, mitochondrial
MOTIF       PS: PS00113  [LIVMFYW](3)-D-G-[FY]-P-R-x(3)-[NQ]
GENES       MJA: MJ0479(adk)
            MTH: MTH27
            ECO: b0474(adk)
            HIN: HI0349(adk)
            HPY: HP0618
            BSU: adk
            MGE: MG171(adk)
            MPN: GT9_orf215(adk)
            SYN: sll1059(adk) sll1815(adk)
            SCE: YDR226W(ADK1) YER170W(ADK2)
            HSA: AK1 AK2
STRUCTURES  PDB: 2AK2  3AKY  4AKE  3ADK  0AKN  1AK2  1AKE  1AKY  1ANK  1DVR  
                 1ZIN  1ZIO  2ECK  2AKY  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.4.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.3
            SCOP (Structural Classificaion of Proteins): 2.7.4.3
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