ENTRY       EC 2.7.1.40
NAME        Pyruvate kinase
            Phosphoenolpyruvate kinase
            Phosphoenol transphosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:pyruvate O2-phosphotransferase
REACTION    ATP + Pyruvate = ADP + Phosphoenolpyruvate;
            UTP + Pyruvate = UDP + Phosphoenolpyruvate;
            GTP + Pyruvate = GDP + Phosphoenolpyruvate;
            CTP + Pyruvate = CDP + Phosphoenolpyruvate;
            ITP + Pyruvate = IDP + Phosphoenolpyruvate;
            dATP + Pyruvate = dADP + Phosphoenolpyruvate
SUBSTRATE   ATP
            UTP
            GTP
            CTP
            ITP
            dATP
            Pyruvate
            Hydroxylamine
            Fluoride
PRODUCT     ADP
            UDP
            GDP
            CDP
            IDP
            dADP
            Phosphoenolpyruvate
            O-Phosphorylhydroxylamine
COFACTOR    CO2
COMMENT     UTP, GTP, CTP, ITP and dATP can also act as donors. Also
            phosphorylates hydroxylamine and fluoride in the presence of CO2.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
DISEASE     MIM: 179050  Pyruvate kinase-3
            MIM: 188555  Thyroid hormone-binding protein, cytosolic (p58)
            MIM: 266200  Pyruvate kinase, liver and RBC type; Anemia,
                         hemolytic, due to PK deficiency (3)
MOTIF       PS: PS00110  [IVA]-x-[LIVM](2)-[SAV]-K-[IV]-E-[NRS]-x-[EQH]-[GAT]-
                         [LIVM]
GENES       MJA: MJ0108
            ECO: b1676(pykF) b1854(pykA)
            HIN: HI1573(pykA)
            BSU: pykA
            MGE: MG216(pyk)
            MPN: H10_orf508(pyk)
            SYN: sll0587(pyk) sll1275(pykF)
            SCE: YAL038W(PYK1) YOR347C(O6342)
            HSA: PKLR(Hs.95990) PKM2(Hs.990)
STRUCTURES  PDB: 1PYK  1PKM  1PKN  1PKY  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.40
            SCOP (Structural Classificaion of Proteins): 2.7.1.40
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