ENTRY EC 2.7.1.37
NAME Protein kinase
Phospharylase b kinase kinase
Glycogen synthase a kinase
Hydroxyalkyl-protein kinase
Serine(threonine) protein kinase
CLASS Transferases
Transferring phosphorus-containing groups
Phosphotransferases with an alcohol group as acceptor
SYSNAME ATP:protein phosphotransferase
REACTION ATP + a Protein = ADP + a Phosphoprotein
SUBSTRATE ATP
Protein
PRODUCT ADP
Phosphoprotein
INHIBITOR Debromoaplysiatoxin
Bryostatins
Teleocidin B-1
12-O-Tetradecanoylphorbol 13-acetate
COMMENT A group of enzymes which are under review by NC-IUBMB.
Other present entries are EC 2.7.1.38, 2.7.1.70, 2.7.1.99,
2.7.1.109-112, 2.7.1.115-6, 2.7.1.123-6, 2.7.1.135 and 2.7.1.141.
Some enzymes are activated by cyclic GMP, but not by cyclic AMP,
and some enzymes by neither.
DISEASE MIM: 115440 Casein kinase-2, alpha-1 polypeptide
MIM: 164731 Murine thymoma viral (v-akt) homolog-2; Ovarian
carcinoma, 167000 (2)
MIM: 311550 PCTAIRE protein kinase 1
MOTIF PS: PS00107 [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
[LIVMFAGCKR]-K
PS: PS00108 [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
PS: PS00888 [LIVM]-[VIC]-x(2)-G-[DENQTA]-x-[GA]-x(2)-[LIVMFY](4)-
x(2)-G
PS: PS00889 [LIVMF]-G-E-x-[GAS]-[LIVM]-x(5,11)-R-[STAQ]-A-x-
[LIVMA]-x-[STACV]
PS: PS01101 C-P-x-[LIVMY]-x-C-x(5)-L-P-[LIVMC]-G-x(9)-V-[KR]-x(2)-
C-P-x-C
PS: PS50003 PH domain profile
PS: PS50004 C2-domain profile
PS: PS50011 Protein kinase domain profile
PS: PS50017 Death domain profile
GENES MTH: MTH1485 MTH283
MPN: K04_orf389
SYN: sll1575 slr0152 slr1225(pknA) slr1443(pknA)
SCE: YGL019W(CKB1) YHR205W(SCH9) YIL035C(CKA1) YJL164C(TPK1)
YKL166C(TPK3) YOR039W(CKB2) YOR061W(CKA2) YPL203W(TPK2)
HSA: PRKAR1A(TSE1) PRKAR1B(Hs.1519) PRKAR2A(PRKAR2)
PRKAR2B(PRKAR2) PRKCA(PKCA) PRKCD(Hs.458) PRKCE PRKCG(PKCG)
PRKCH(PKC-L) PRKCM(PKCM) PRKCQ(Hs.89615) PRKCSH(G19P1)
PRKCZ(Hs.78793)
STRUCTURES PDB: 1YDS 1YDR 1TBI 1RGS 1HCL 1HCK 1YDT 1CDK 1BPK 1ATP
1APM 1APK 2APK 2BPK 2CPK 1CMK 1CTP
DBLINKS University of Geneva ENZYME DATA BANK: 2.7.1.37
WIT (What Is There) Metabolic Reconstruction: 2.7.1.37
SCOP (Structural Classificaion of Proteins): 2.7.1.37
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