ENTRY       EC 2.7.1.137
NAME        1-Phosphatidylinositol 3-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
REACTION    ATP + 1-Phosphatidyl-1D-myo-inositol =
            ADP + 1-Phosphatidyl-1D-myo-inositol 3-phosphate
SUBSTRATE   ATP
            1-Phosphatidyl-1D-myo-inositol
PRODUCT     ADP
            1-Phosphatidyl-1D-myo-inositol 3-phosphate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DISEASE     MIM: 171834  Phosphatidylinositol 3-kinase, catalytic, alpha
                         polypeptide
MOTIF       PS: PS00915  [LIVMFAC]-K-x(1,3)-[DE](2)-[LIVMC]-R-Q-[DE]-x(4)-Q
            PS: PS00916  [GS]-x-A-x(3)-[LIVM]-x(2)-[FYH]-[LIVM](2)-x-[LIVMF]-x-
                         D-R-H-x(2)-N
            PS: PS50004  C2-domain profile
GENES       SCE: YJR066W(TOR1) YKL203C(TOR2) YLR240W(VPS34)
            HSA: PIK3CA PIK3CB(PIK3C1) PIK3CG(Hs.32942)
STRUCTURES  PDB: 2PNB  2PNA  1PKT  1PKS  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.137
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.137
            SCOP (Structural Classificaion of Proteins): 2.7.1.137
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