ENTRY       EC 2.7.1.127
NAME        1D-myo-Inositol-triphosphate 3-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase
REACTION    ATP + 1D-myo-Inositol 1,4,5-trisphosphate = ADP +
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
SUBSTRATE   ATP
            1D-myo-Inositol 1,4,5-trisphosphate
PRODUCT     ADP
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
EFFECTOR    Ca2+
COMMENT     Activated by Ca2+.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DISEASE     MIM: 147521  Inositol 1,4,5-trisphosphate 3-kinase A
            MIM: 147522  Inositol 1,4,5-trisphosphate 3-kinase B
GENES       HSA: ITPKA(Hs.2722) ITPKB(Hs.78877)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.127
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.127
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