ENTRY       EC 2.7.1.126
NAME        beta-Adrenergic-receptor kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:beta-adrenergic-receptor phosphotransferase
REACTION    ATP + beta-Adrenergic receptor =
            ADP + Phospho-beta-adrenergic receptor
SUBSTRATE   ATP
            beta-Adrenergic receptor
            Rhodopsin
PRODUCT     ADP
            Phospho-beta-adrenergic receptor
INHIBITOR   Zn2+
            Digitonin
COMMENT     Acts on the agonist-occupied form of the receptor; also
            phosphorylates rhodopsin, but more slowly. Does not act on casein
            or histones. Inhibited by Zn2+ and digitonin; unaffected by
            cyclic-AMP. (cf. EC 2.7.1.125). See comment on EC 2.7.1.37.
DISEASE     MIM: 109635  Adrenergic, beta, receptor kinase-1
            MIM: 109636  Adrenergic, beta, receptor kinase 2
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50003  PH domain profile
            PS: PS50011  Protein kinase domain profile
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.126
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.126
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