ENTRY       EC 2.7.1.125
NAME        Rhodopsin kinase
            Opsin kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:rhodopsin phosphotransferase
REACTION    ATP + Rhodopsin = ADP + Phosphorhodopsin
SUBSTRATE   ATP
            Rhodopsin
            beta-Adrenergic receptor
PRODUCT     ADP
            Phosphorhodopsin
INHIBITOR   Zn2+
            Digitonin
COMMENT     Acts on the bleached or activated form of rhodopsin; also
            phosphorylates the beta-adrenergic receptor, but more slowly.
            Does not act on casein, histones or phosphvitin. Inhibited by
            Zn2+ and Digitonin. (cf. EC 2.7.1.126)
DISEASE     MIM: 180381  Rhodopsin kinase; Oguchi disease-2, 258100 (3)
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50011  Protein kinase domain profile
GENES       HSA: RHOK(GRK1)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.125
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.125
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