ENTRY       EC 2.7.1.123
NAME        Ca2+/calmodulin-dependent protein kinase
            Microtubule-associated protein 2 kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:protein O-phosphotransferase (calmodulin-dependent)
REACTION    ATP + Protein = ADP + O-Phosphoprotein
SUBSTRATE   ATP
            Protein
            Vimentin
            Synapsin
            Glycogen synthase
            Myosin light chain
PRODUCT     ADP
            O-Phosphoprotein
COFACTOR    Calmodulin
            Ca2+
COMMENT     Requires calmodulin and Ca2+. A wide range of proteins can act as
            acceptor, including vimentin, synapsin, glycogen synthases,
            myosin light chains and the microtubule-associated tau protein.
            Not identical with EC 2.7.1.117, 2.7.1.120 or 2.7.1.135.
DISEASE     MIM: 114080  Ca(2+)-calmodulin-dependent protein kinase type IV of
                         brain
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50011  Protein kinase domain profile
GENES       SYN: slr1697(pknA)
            SCE: YFR014C(CMK1) YOL016C(CMK2)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.123
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.123
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