ENTRY       EC 2.7.1.117
NAME        Myosin-light-chain kinase
            Myosin kinase
            Smooth-muscle-myosin-light-chain kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:myosin-light-chain O-phosphotransferase
REACTION    ATP + Myosin light chain = ADP + Myosin light chain phosphate
SUBSTRATE   ATP
            Myosin light chain
PRODUCT     ADP
            Myosin light chain phosphate
COFACTOR    Ca2+
            Calmodulin
COMMENT     Requires Ca2+ and calmodulin. The 20-kDa light chain from smooth
            muscle myosin is phosphorylated more rapidly than any other
            acceptor, but light chains from other myosins and myosin itself
            can act as acceptors, more slowly.
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50011  Protein kinase domain profile
GENES       HSA: MYLK
STRUCTURES  PDB: 1TLK  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.117
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.117
            SCOP (Structural Classificaion of Proteins): 2.7.1.117
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