ENTRY       EC 2.6.1.5
NAME        Tyrosine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Tyrosine:2-oxoglutarate aminotransferase
REACTION    L-Tyrosine + 2-Oxoglutarate = 3-(4-Hydroxyphenyl)pyruvate +
            L-Glutamate
SUBSTRATE   L-Tyrosine
            L-Phenylalanine
            2-Oxoglutarate
PRODUCT     3-(4-Hydroxyphenyl)pyruvate
            Phenylpyruvate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. L-Phenylalanine can act instead
            of L-tyrosine. The mitochondrial enzyme may be identical with
            EC 2.6.1.1 (= Aspartate aminotransferase). The three isoenzymic
            forms are interconverted by EC 3.4.22.4.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
DISEASE     MIM: 276600  Tyrosine aminotransferase, cytosolic; Tyrosinemia,
                         type II (3)
MOTIF       PS: PS00105  [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-
                         [GNAR]-x-R-[LIVMA]-[GA]
GENES       ECO: b4054(tyrB)
            HSA: TAT(Hs.2999)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.6.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.5
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