ENTRY       EC 2.6.1.42
NAME        Branched-chain-amino-acid transaminase
            Transaminase B
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Branched-chain-amino-acid:2-oxoglutarate aminotransferase
REACTION    L-Leucine + 2-Oxoglutarate = 4-Methyl-2-oxopentanoate +
            L-Glutamate
SUBSTRATE   L-Leucine
            L-Isoleucine
            L-Valine
            2-Oxoglutarate
PRODUCT     4-Methyl-2-oxopentanoate
            L-Glutamate
            3-Methyl-2-oxopentanoate
            3-Methyl-2-oxobutanoate
COFACTOR    Pyridoxal phosphate
COMMENT     Also acts on L-isoleucine and L-valine. Different from
            EC 2.6.1.66.
            (EC 2.6.1.66 Valine-pyruvate aminotransferase)
            A pyridoxal-phosphate protein (J.Biochem.,104,777-784 (1988)).
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00770  Pantothenate and CoA biosynthesis
MOTIF       PS: PS00770  N-[LIVM]-F-x(2)-K-x(3)-[LIVM]-[FY]-T-x(7)-[LIVM]-x-G-
                         [LIVM]-x-R
GENES       MJA: MJ1008
            MTH: MTH1430
            ECO: b3770(ilvE)
            HIN: HI1193(ilvE)
            HPY: HP1468(ilvE)
            BSU: yheM ywaA(ipa-0r)
            SYN: slr0032
            SCE: YHR208W(TWT1) YJR148W(J2209)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.6.1.42
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.42
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