ENTRY       EC 2.6.1.26
NAME        Thyroid-hormone transaminase
            3,5-Dinitrotyrosine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-3,5,3'-Triiodothyronine:2-oxoglutarate aminotransferase
REACTION    L-3,5,3'-Triiodothyronine + 2-Oxoglutarate =
            3,5,3'-Triiodophenylpyruvate + L-Glutamate
SUBSTRATE   L-3,5,3'-Triiodothyronine
            2-Oxoglutarate
            3,5-Diiodo-L-tyrosine
            Thyroxine
            3,5-Dinitro-L-tyrosine
            Pyruvate
            Oxaloacetate
PRODUCT     3,5,3'-Triiodophenylpyruvate
            L-Glutamate
            3,5-Diiodo-4-hydroxyphenylpyruvate
            3,5-Dinitro-4-hydroxyphenylpyruvate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Acts on monoiodotyrosine,
            diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine.
            (unlike EC 2.6.1.24, which does not act on dinitrotyrosine).
            Pyruvate or oxaloacetate can act as acceptors.
GENES       HSA: BCAT1(BCT1) BCAT2(BCT2)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.6.1.26
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.26
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