ENTRY       EC 2.6.1.1
NAME        Aspartate transaminase
            Glutamic-oxaloacetic transaminase
            Glutamic-aspartic transaminase
            Transaminase A
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Aspartate:2-oxoglutarate aminotransferase
REACTION    L-Aspartate + 2-Oxoglutarate = Oxaloacetate + L-Glutamate
SUBSTRATE   L-Aspartate
            L-Tyrosine
            L-Phenylalanine
            L-Tryptophan
            2-Oxoglutarate
PRODUCT     Oxaloacetate
            L-Glutamate
            3-(4-Hydroxyphenyl)pyruvate
            Phenylpyruvate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Acts also on L-tyrosine, L-phenyl-
            alanine and L-tryptophan. This acticity can be formed from EC
            2.6.1.57 by controlled proteolysis.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00252  Alanine and Aspartate metabolism
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            PATH: MAP00710  Carbon fixation
DISEASE     MIM: 138150  Glutamic-oxaloacetic transaminase-2, mitochondrial (EC
                         2.6.1.1)
            MIM: 138180  Glutamic-oxaloacetic transaminase-1, soluble (EC
                         2.6.1.1)
MOTIF       PS: PS00105  [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-
                         [GNAR]-x-R-[LIVMA]-[GA]
GENES       MJA: MJ0001 MJ0684 MJ1391
            MTH: MTH1601 MTH1694 MTH1894 MTH52
            ECO: b0928(aspC)
            HIN: HI1617(aspC)
            BSU: aspB ykrV yugH
            SYN: sll0006(aspC) sll0402(aspC) sll0938 slr0036(aspC)
            SCE: YKL106W(AAT1) YLR027C(AAT2)
            HSA: GOT1(Hs.597) GOT2(Hs.79365)
STRUCTURES  PDB: 0MAA  1AAM  1AAT  1AAW  1AHE  1AHF  1AHG  1AHX  1AHY  1AIA  
                 1AIB  1AIC  1AKA  1AKB  1AKC  1AMA  1AMQ  1AMR  1AMS  1ARG  
                 1ARH  1ARI  1ARS  1ART  1ASA  1ASB  1ASC  1ASD  1ASE  1ASF  
                 1ASG  1ASL  1ASM  1ASN  1MAP  1MAQ  1OXO  1OXP  1SPA  1TAR  
                 1TAS  1TAT  2AAT  2CST  3AAT  7AAT  8AAT  9AAT  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.6.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.1
            SCOP (Structural Classificaion of Proteins): 2.6.1.1
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