ENTRY       EC 2.5.1.6
NAME        Methionine adenosyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     ATP:L-methione S-adenosyltransferase
REACTION    ATP + L-Methionine + H2O = Orthophosphate + Pyrophosphate +
            S-Adenosyl-L-methionine
SUBSTRATE   ATP
            L-Methionine
            H2O
PRODUCT     Orthophosphate
            Pyrophosphate
            S-Adenosyl-L-methionine
COMMENT     Formerly EC 2.4.2.13.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
DISEASE     MIM: 250850  Methionine adenosyltransferase I, alpha;
                         Hypermethioninemia, persistent, autosomal dominant, due
                         to methionine adenosyltransferase I/III deficiency (3)
            MIM: 601468  Methionine adenosyltransferase II, alpha
MOTIF       PS: PS00376  G-A-G-D-Q-G
            PS: PS00377  G-[GA]-G-A-F-S-x-K-[DE]
GENES       ECO: b2942(metK)
            HIN: HI1172(metK)
            HPY: HP0197(metX)
            BSU: metK(metE)
            MGE: MG047(metX)
            MPN: D09_orf383(metK)
            SYN: sll0927(metX)
            SCE: YDR502C(SAM2) YLR180W(SAM1)
STRUCTURES  PDB: 1XRC  1XRB  1XRA  1MXC  1MXB  1MXA  1FUG  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.5.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.6
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