ENTRY       EC 2.5.1.40
NAME        Aristolochene synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     trans,trans-Farnesyl-diphosphate farnesyltransferase (bicyclizing)
REACTION    trans,trans-Farnesyl diphosphate = Pyrophosphate + Aristolochene
SUBSTRATE   trans,trans-Farnesyl diphosphate
PRODUCT     Pyrophosphate
            Aristolochene
COMMENT     The initial internal transfer of the farnesyl group to the C-10
            position preduces the monocyclic intermediate germacrene A;
            further cyclization and methyl transfer converts the intermediate
            into aristolochene.
PATHWAY     PATH: MAP00900  Terpenoid biosynthesis
DBLINKS     University of Geneva ENZYME DATA BANK: 2.5.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.40
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