ENTRY       EC 2.5.1.37
NAME        Leukotriene-C4 synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate:
            $glutathione leukotriene-transferase (epoxide-ring-opening)
REACTION    Leukotriene A4 + Glutathione = Leukotriene C4 + H2O
SUBSTRATE   Leukotriene A4
            Glutathione
PRODUCT     Leukotriene C4
            H2O
COMMENT     Not identical with EC 2.5.1.8.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
DISEASE     MIM: 246530  Leukotriene C4 synthase; Leukotriene C4 synthase
                         deficiency (1)
GENES       HSA: LTC4S(Hs.456)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.5.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.37
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