ENTRY       EC 2.5.1.10
NAME        Geranyltranstransferase
            Farnesyl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Geranyl-diphosphate:isopentenyl-diphosphate geranyltrans-
            transferase
REACTION    Geranyl diphosphate + Isopentenyl diphosphate = Pyrophosphate +
            trans,trans-Farnesyl diphosphate
SUBSTRATE   Geranyl diphosphate
            Isopentenyl diphosphate
            Dimethylallyl diphosphate
PRODUCT     Pyrophosphate
            trans,trans-Farnesyl diphosphate
            Geranyl diphosphate
COMMENT     Some forms of this enzyme will also use dimethylallyl
            diphosphate as a substrate. The enzyme will not accept larger
            prenyl diphosphates as efficient donors.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
DISEASE     MIM: 134631  Farnesyl diphosphate synthase-like 1 (farnesyl
                         pyrophosphate
MOTIF       PS: PS00444  [LIVMFY]-G-x(2)-[FY]-Q-[LIVM]-x-D-D-[LIVMFY]-x-[DNG]
            PS: PS00723  [LIVM](2)-x-D-D-x(2,4)-D-x(4)-R-R-G
GENES       MJA: MJ0860(idsA)
            MTH: MTH50(idsA)
            ECO: b0421(ispA)
            HIN: HI1438(ispA)
            HPY: HP0929(ispA)
            BSU: yqiD
            SYN: slr0739(crtE_2)
            SCE: YJL167W(FPP1)
STRUCTURES  PDB: 1FPS  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.5.1.10
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.10
            SCOP (Structural Classificaion of Proteins): 2.5.1.10
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