ENTRY       EC 2.4.2.8
NAME        Hypoxanthine phosphoribosyltransferase
            Hypoxanthine--guanine phosphoribosyltransferase
            IMP pyrophospharylase
            Transphosphoribosidase
            Guanine phosphoribosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     IMP:pyrophosphate phosphoribosyltransferase
REACTION    IMP + Pyrophosphate = Hypoxanthine +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   IMP
            Pyrophosphate
            9-(5-Phospho-1-ribofuranosyl)-6-mercaptopurine
            GMP
PRODUCT     Hypoxanthine
            Guanine
            6-Mercaptopurine
            5-Phospho-alpha-D-ribose 1-diphosphate
COMMENT     Guanine and 6-mercaptopurine can replace hypoxanthine.
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 308000  Hypoxanthine phosphoribosyltransferase; Lesch-Nyhan
                         syndrome (3); HPRT-related gout (3)
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM](2)-[LIVMF]-[DE]-D-[LIVMS]-[LIVM]-
                         [STAVD]-[STAR]-[GAC]-x-[STAR]
GENES       ECO: b0125(hpt)
            HIN: HI1153(hpt)
            BSU: hprT(hpt)
            MGE: MG458(hpt)
            MPN: K05_orf175(hpt)
            HSA: HPRT1(HPRT)
STRUCTURES  PDB: 1HMP  1HGX  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.2.8
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.8
            SCOP (Structural Classificaion of Proteins): 2.4.2.8
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