ENTRY       EC 2.4.2.7
NAME        Adenine phosphoribosyltransferase
            AMP pyrophosphorylase
            Transphosphoribosidase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     AMP:pyrophosphate phosphoribosyltransferase
REACTION    AMP + Pyrophosphate = Adenine +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   AMP
            Pyrophosphate
            5-Amino-1-ribofuranosylimidazole-4-carboxyamide
PRODUCT     Adenine
            5-Phospho-alpha-D-ribose 1-diphosphate
            5-Amino-4-imidazolecarboxyamide
COMMENT     5-Amino-4-imidazolecarboxyamide can replace adenine.
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 102600  Adenine phosphoribosyltransferase; Urolithiasis,
                         2,8-dihydroxyadenine (3)
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM](2)-[LIVMF]-[DE]-D-[LIVMS]-[LIVM]-
                         [STAVD]-[STAR]-[GAC]-x-[STAR]
GENES       MJA: MJ1655(apt)
            ECO: b0469(apt)
            HIN: HI1230(apt)
            HPY: HP0572
            BSU: apt
            MGE: MG276(apt)
            MPN: F11_orf133(apt)
            SYN: sll1430(apt)
            SCE: YDR441C(APT2) YML022W(APT1)
            HSA: APRT
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.2.7
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.7
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