ENTRY       EC 2.4.2.14
NAME        Amidophosphoribosyltransferase
            Phosphoribosyldiphosphate 5-amidotransferase
            Glutamine phosphoribosylpyrophosphate amidotransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     5-Phosphoribosylamine:pyrophosphate phosphoribosyltransferase
            (glutamate-amidating)
REACTION    5-Phospho-beta-D-ribosylamine + Pyrophosphate + L-Glutamate =
            L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O
SUBSTRATE   5-Phospho-beta-D-ribosylamine
            Pyrophosphate
            L-Glutamate
PRODUCT     L-Glutamine
            5-Phospho-alpha-D-ribose 1-diphosphate
            H2O
COMMENT     Has 4Fe-4S cluster. Type F glutamine amidotransferase.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00251  Glutamate metabolism
DISEASE     MIM: 172450  Phosphoribosylpyrophosphate amidotransferase
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM](2)-[LIVMF]-[DE]-D-[LIVMS]-[LIVM]-
                         [STAVD]-[STAR]-[GAC]-x-[STAR]
            PS: PS00443  <x(0,11)-C-[GS]-[IV]-[LIVMFYW]-[AG]
GENES       MJA: MJ0204
            MTH: MTH191 MTH646
            ECO: b2312(purF)
            HIN: HI1207(purF)
            BSU: purF(purB)
            SYN: sll0757(purF)
            SCE: YMR300C(ADE4)
            HSA: PPAT(GPAT)
STRUCTURES  PDB: 1ECF  1ECG  1GPH  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.2.14
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.14
            SCOP (Structural Classificaion of Proteins): 2.4.2.14
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