ENTRY       EC 2.4.2.10
NAME        Orotate phosphoribosyltransferase
            Orotidylic acid phosphorylase
            Orotidine-5'-phosphate pyrophosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Orotidine-5'-phosphate:pyrophosphate phosphoribosyltransferase
REACTION    Orotidine 5'-phosphate + Pyrophosphate = Orotate +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   Orotidine 5'-phosphate
            Pyrophosphate
PRODUCT     Orotate
            5-Phospho-alpha-D-ribose 1-diphosphate
            UMP
            CO2
COMMENT     The enzyme from higher eucaryotes also catalyses the reaction
            listed as EC 4.1.1.23.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM](2)-[LIVMF]-[DE]-D-[LIVMS]-[LIVM]-
                         [STAVD]-[STAR]-[GAC]-x-[STAR]
            PS: PS00156  [LIVMFTA]-[LIVMF]-x-D-x-K-x(2)-D-I-[GP]-x-T-[LIVMTA]
GENES       MJA: MJ1109
            ECO: b3642(pyrE)
            HIN: HI0272(pyrE)
            HPY: HP1257(pyrE)
            BSU: pyrE(pyrX)
            SYN: slr0185(umpS)
            SCE: YML106W(URA5) YMR271C(URA10)
            HSA: UMPS(Hs.2057)
STRUCTURES  PDB: 1ORO  1STO  1OPR  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.2.10
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.10
            SCOP (Structural Classificaion of Proteins): 2.4.2.10
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