ENTRY EC 2.3.2.5
NAME Glutaminyl-peptide cyclotransferase
Glutaminyl-tRNA cyclotransferase
Glutaminyl cyclase
CLASS Transferases
Acyltransferases
Aminoacyltransferases
SYSNAME L-Glutaminyl-peptide gamma-gluramyltransferase (cyclizing)
REACTION L-Glutaminyl-peptide = 5-Oxoprolyl-peptide + NH3
SUBSTRATE L-Glutaminyl-peptide
Glutaminyl-tRNA
PRODUCT 5-Oxoprolyl-peptide
NH3
5-Oxoprolyl-tRNA
COMMENT Involved in the formation of thyrotropin-releasing hormone and
other biologically active peptides containing N-terminal
pyroglutamyl residues. The enzyme from papaya also acts on
glutaminyl-tRNA.
DBLINKS University of Geneva ENZYME DATA BANK: 2.3.2.5
WIT (What Is There) Metabolic Reconstruction: 2.3.2.5
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