ENTRY       EC 2.3.1.37
NAME        5-Aminolevulinate synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating)
REACTION    Succinyl-CoA + Glycine = 5-Aminolevulinate + CoA + CO2
SUBSTRATE   Succinyl-CoA
            Glycine
PRODUCT     5-Aminolevulinate
            CoA
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The enzyme in erythrocytes is
            genetically distinct from that in other tissues.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DISEASE     MIM: 125290  Aminolevulinate, delta-, synthase-1
            MIM: 301300  Aminolevulinate, delta-, synthase-2; Anemia,
                         sideroblastic/hypochromic (3)
MOTIF       PS: PS00599  T-[LIVMFYW]-[STAG]-K-[SAG]-[LIVMFYWR]-[SAG]-x(2)-[SAG]
GENES       SCE: YDR232W(HEM1)
            HSA: ALAS1(ALAS) ALAS2(ASB)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.3.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.37
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