ENTRY       EC 2.1.3.2
NAME        Aspartate carbamoyltransferase
            Carbamylaspartotranskinase
            Aspartate transcarbamylase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:L-aspartate carbamoyltransferase
REACTION    Carbamoyl phosphate + L-Aspartate = Orthophosphate +
            N-Carbamoyl-L-aspartate
SUBSTRATE   Carbamoyl phosphate
            L-Aspartate
PRODUCT     Orthophosphate
            N-Carbamoyl-L-aspartate
INHIBITOR   CTP
            UTP
EFFECTOR    ATP
COMMENT     The formation of cytidine triphosphate in E. coli is controlled by
            feedback (end-product) inhibiton.  As a critical concentration of
            CTP is build up, CTP slows down its own formation by inhibiting
            this enzyme.  This enzyme is composed of two large subunits, one
            of which carries the catalytic site and the other the regulatory
            site.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00252  Alanine and Aspartate metabolism
MOTIF       PS: PS00097  F-x-[EK]-x-S-[GT]-R-T
            PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QE]-x-[LIVMFA]
            PS: PS00482  D-[LIVMFYWSP]-H-[LIV]-H-[LIVF]-[RN]-x-[PG]
            PS: PS00483  [GA]-[ST]-D-x-A-P-H-x(4)-K
            PS: PS00866  [FYV]-P-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-x(3)-
                         [SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
GENES       MJA: MJ1406 MJ1581
            MTH: MTH1413 MTH850
            ECO: b4244(pyrI) b4245(pyrB)
            HPY: HP1084(pyrB)
            BSU: pyrB
            SYN: slr1476(pyrB)
            SCE: YJL130C(URA2)
            HSA: CAD
STRUCTURES  PDB: 0ACS  1ACM  1AT1  1RAA  1RAB  1RAC  1RAD  1RAE  1RAF  1RAG  
                 1RAH  1RAI  2AT1  2AT2  2ATC  3AT1  4AT1  5AT1  6AT1  7AT1  
                 8AT1  8ATC  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.3.2
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.2
            SCOP (Structural Classificaion of Proteins): 2.1.3.2
///