ENTRY       EC 2.1.2.1
NAME        Glycine hydroxymethyltransferase
            Serine aldolase
            Threonine aldolase
            Serine hydroxymethylase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
REACTION    5,10-Methylenetetrahydrofolate + Glycine + H2O = Tetrahydrofolate
            + L-Serine
SUBSTRATE   5,10-Methylenetetrahydrofolate
            Acetaldehyde
            4-Trimethylammoniobutanal
            Glycine
            H2O
PRODUCT     Tetrahydrofolate
            L-Serine
            L-Threonine
            3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also catalyses the reaction of
            glycine with acetaldehyde to form L-threonine, and with
            4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-
            L-lysine.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00310  Lysine degradation
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00670  One carbon pool by folate
            PATH: MAP00680  Methane metabolism
            PATH: MAP00750  Vitamin B6 metabolism
DISEASE     MIM: 138450  Serine hydroxymethyltransferase
            MIM: 182144  Serine hydroxymethyltransferase (soluble)
MOTIF       PS: PS00096  [ST](4)-H-K-[ST]-L-x-G-x-R-[GSA](2)
GENES       MJA: MJ1597(glyA)
            MTH: MTH1380(glyA)
            ECO: b2551(glyA)
            HIN: HI0889(glyA)
            HPY: HP0183(glyA)
            BSU: glyA(glyC)
            MGE: MG394(glyA)
            MPN: D02_orf406(glyA)
            SYN: sll1931(gylA)
            SCE: YBR263W(SHM1) YDL198C(YHM1) YLR058C(SHM2)
            HSA: SHMT2(SHMT)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.1
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