ENTRY       EC 1.9.3.1
NAME        Cytochrome-c oxidase
            Cytochrome oxidase
            Cytochrome a3
            Cytochrome aa3
CLASS       Oxidoreductases
            Acting on heme group of donors
            With oxygen as acceptor
SYSNAME     Ferrocytochrome-c:oxygen oxidoreductase
REACTION    4 Ferrocytochrome c + O2 = 4 Ferricytochrome c + 2 H2O
SUBSTRATE   Ferrocytochrome c
            O2
PRODUCT     Ferricytochrome c
            H2O
COMMENT     A cytochrome of the a type containing copper.
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
DISEASE     MIM: 123864  Cytochrome c oxidase, subunit IV
            MIM: 123866  Cytochrome c oxidase, subunit Vb
            MIM: 123870  Cytochrome c oxidase, subunit VIII
            MIM: 124089  Cytochrome c oxidase VIb
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00077  W-x-H-H-[LMF]
            PS: PS00078  C-[SA]-x(2)-C-G-x(2)-H
            PS: PS00848  [LIVM](2)-[FYW]-x(10)-C-x(2)-C-G-x(2)-[FY]-K-L
GENES       HPY: HP0144(fixN) HP0145(fixO)
            BSU: ctaC ctaD ctaE ctaF
            SYN: sll0813(ctaC) sll1899(ctaB) slr1136(ctaC) slr1137(ctaD)
                 slr1138(ctaE) slr2082(ctaD) slr2083(ctaE)
            SCE: YDL067C(COX9) YGL187C(COX4) YGL191W(COX13) YHR051W(COX6)
                 YIL111W(COX5B) YLR038C(COX12) YLR395C(COX8) YMR256C(COX7)
                 YNL052W(COX5A)
            HSA: COX4(Hs.686) COX5B(Hs.1342) COX5BL4 COX6A1(COX6A) COX6A2
                 COX6B(Hs.83379) COX6C(Hs.74649) COX7A1(COX7A) COX7A2(Hs.2321)
                 COX8
STRUCTURES  PDB: 1OCC  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.9.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.9.3.1
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