ENTRY       EC 1.5.99.4
NAME        Nicotine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     Nicotine:(acceptor) 6-oxidoreductase (hydroxylating)
REACTION    Nicotine + Acceptor + H2O = (S)-6-Hydroxynicotine +
            Reduced acceptor
SUBSTRATE   Nicotine
            Acceptor
            H2O
PRODUCT     (S)-6-Hydroxynicotine
            Reduced acceptor
COFACTOR    FMN
            Metal
COMMENT     A metalloprotein (FMN).  Acts on both (R)- and (S)-isomers.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.5.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.4
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