ENTRY       EC 1.5.1.12
NAME        1-Pyrroline-5-carboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1-Pyrroline-5-carboxylate:NAD+ oxidoreductase
REACTION    L-1-Pyrroline-5-carboxylate + NAD+ + H2O =
            L-Glutamate + NADH
SUBSTRATE   L-1-Pyrroline-5-carboxylate
            NAD+
            H2O
            L-1-Pyrroline-3-hydroxy-5-carboxylate
PRODUCT     L-Glutamate
            NADH
            4-Hydroxy-L-glutamate
COMMENT     Oxidizes other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-
            -carboxylate forms 4-hydroxyglutamate.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00330  Arginine and proline metabolism
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTNC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTA]-[GS]-G-[KNM]-[SADN]-[TAPFV]
GENES       ECO: b1014(putA)
            HPY: HP0056
            BSU: rocA(ipa-76d)
            SYN: sll1561(putA)
            SCE: YHR037W(PUT2)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.5.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.12
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