ENTRY       EC 1.4.4.2
NAME        Glycine dehydrogenase (decarboxylating)
            Glycine decarboxylase
            P-Protein
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With a disulfide as acceptor
SYSNAME     Glycine:lipoylprotein oxidoreductase (decarboxylating and
            acceptor-aminomethylating)
REACTION    Glycine + Lipoylprotein = S-Aminomethyldihydrolipoylprotein +
            CO2
SUBSTRATE   Glycine
            Lipoylprotein
            Lipoamide
PRODUCT     S-Aminomethyldihydrolipoylprotein
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Lipoamide can also act as
            acceptor. A component, with EC 2.1.2.10, of the glycine
            cleavage system, previously known as glycine synthase.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DISEASE     MIM: 238300  Glycine dehydrogenase (decarboxylating; glycine
                         decarboxylase, glycine; Hyperglycinemia, nonketotic,
                         type I (3)
GENES       ECO: b2903(gcvP)
            BSU: yqhJ yqhK
            SYN: slr0293(gcvP)
            SCE: YMR189W(GCV2)
            HSA: GLDC(Hs.27)
STRUCTURES  PDB: 1HPC  1HTP  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.4.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.4.4.2
            SCOP (Structural Classificaion of Proteins): 1.4.4.2
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