ENTRY       EC 1.4.3.6
NAME        Amine oxidase (copper-containing)
            Diamine oxidase
            Diamino oxhydrase
            Histaminase
            Amine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Amine:oxygen oxidoreductase (deaminating) (copper-containing)
REACTION    RCH2NH2 + H2O = RCHO + NH3 + H2O2
SUBSTRATE   RCH2NH2
            H2O
            Primary monoamine
            Primary diamine
            Histamine
PRODUCT     RCHO
            NH3
            H2O2
COFACTOR    Copper
            PQQ
COMMENT     A group of enzymes including those oxidizing primary monoamines,
            diamines and histamine. They are copper quinoproteins.  One form
            of EC 1.3.1.15 from rat kidney also catalyses this reaction.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00410  beta-Alanine metabolism
DISEASE     MIM: 104610  Amiloride-binding protein-1
GENES       ECO: b1386(tynA)
            HSA: ABP1(AOC1)
STRUCTURES  PDB: 1OAC  1SPU  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.4.3.6
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.6
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