ENTRY       EC 1.4.1.9
NAME        Leucine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Leucine:NAD+ oxidoreductase(deaminating)
REACTION    L-Leucine + H2O + NAD+ = 4-Methyl-2-oxopentanoate + NH3 + NADH
SUBSTRATE   L-Leucine
            H2O
            NAD+
            L-Isoleucine
            L-Valine
            L-Norvaline
            L-Norleucine
PRODUCT     4-Methyl-2-oxopentanoate
            NH3
            NADH
            3-Methyl-2-oxopentanoate
            3-Methyl-2-oxobutanoate
            2-Oxopentanoate
            2-Oxohexanoate
COMMENT     Also acts on isoleucine, valine, norvaline and norleucine.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
MOTIF       PS: PS00074  [LIV]-x(2)-G-G-[SAG]-K-x-[GV]-x(3)-[DNS]-[PL]
GENES       BSU: yqiT
STRUCTURES  PDB: 1LEH  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.4.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.9
///