ENTRY       EC 1.3.99.11
NAME        Dihydroorotate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     (S)-Dihydroorotate:(acceptor) oxidoreductase
REACTION    (S)-Dihydroorotate + Acceptor = Orotate + Reduced acceptor
SUBSTRATE   (S)-Dihydroorotate
            Acceptor
            O2
            2,6-Dichloroindophenol
            1,10-Phenanthroline
PRODUCT     Orotate
            Reduced acceptor
            H2O
            2,6-Dichlorophenol-4-(p-benzoquinone imine)
COFACTOR    Iron
            Zinc
COMMENT     An iron-zinc protein. Oxygen can act as acceptor, but much
            more slowly than 2,6-dichloroindophenol or 1,10-phenanthroline.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       HPY: HP1011(pyrD)
            BSU: pyrD(pyrDI)
            SYN: slr1418(pyrD)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.3.99.11
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.11
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