ENTRY       EC 1.3.3.4
NAME        Protoporphyrinogen oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     Protoporphyrinogen-IX:oxygen oxidoreductase
REACTION    Protoporphyrinogen-IX + O2 = Protoporphyrin-IX + H2O
SUBSTRATE   Protoporphyrinogen-IX
            O2
PRODUCT     Protoporphyrin-IX
            H2O
COMMENT     Also slowly oxidizes mesoporphyrinogen-IX.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DISEASE     MIM: 600923  Protoporphyrinogen oxidase; Porphyria variegata,
                         176200 (3)
GENES       ECO: b3850(hemG)
            HPY: HP0381(hemK)
            BSU: hemY(hemG)
            MGE: MG259(hemK)
            MPN: H91_orf453
            SYN: sll1237(hemK)
            SCE: YER014W(HEM14)
            HSA: PPOX(PPO)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.3.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.4
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