ENTRY       EC 1.2.1.3
NAME        Aldehyde dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aldehyde:NAD+ oxidoreductase
REACTION    Aldehyde + NAD+ + H2O = Carboxylate + NADH
SUBSTRATE   Aldehyde
            D-Glucuronolactone
            NAD+
            H2O
PRODUCT     Carboxylate
            D-Glucarate
            NADH
COMMENT     Wide specificity, including oxidation of D-glucuronolactone
            to D-glucarate. Formerly EC 1.1.1.70
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00310  Lysine degradation
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
DISEASE     MIM: 100640  Aldehyde dehydrogenase-1, soluble
            MIM: 100650  Aldehyde dehydrogenase-2, mitochondrial; Alcohol
                         intolerance, acute (3); {?Fetal alcohol syndrome} (1)
            MIM: 100670  Aldehyde dehydrogenase-5
            MIM: 270200  Aldehyde dehydrogenase 10 (fatty aldehyde
                         dehydrogenase); Sjogren-Larsson syndrome (3)
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTNC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTA]-[GS]-G-[KNM]-[SADN]-[TAPFV]
GENES       ECO: b1300(aldH)
            BSU: aldX(yxaS) ycbD ywdH(ipa-58r)
            SYN: slr0091
            SCE: YER073W(ALD3) YPL061W(ALD6)
            HSA: ALDH1(PUMB1) ALDH2(Hs.74630) ALDH3(Hs.575) ALDH5(ALDHX)
                 ALDH6(Hs.75746) ALDH7(Hs.3116)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.3
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